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Former NHL executive Daniel Carcillo paved the way for psychiatry to treat TBI to treat post-concussion syndrome

Former NHL executive Daniel Carcillo paved the way for psychiatry to treat TBI to treat post-concussion syndrome

Research. Sometimes that’s all there is to it.

Although they need light sensitivity and sound sensitivity and a dark room.

Despite losing memory, you feel a headache and headache in a mink.

Despite the inability to concentrate.

Despite being told to stay away from computers and smartphones and relax the brain.

Finding an outlet consumes. It consumes all research.

Daniel Carcillo knows all too well.

At the age of 30, the NHL executive was forced into early retirement in 2015 after being diagnosed with a seventh stroke. After 429 games spread over 11 seasons, his career ended with his second Stanley Cup. The next four years led him to commit suicide in an attempt to get out of a weak fight with post-concussion syndrome.

“Read a lot of medical papers about bruises, visit [a] the brain bank, CT pathologists, “Carcillo said.” Doing a lot of things to try to manage the symptoms, that’s what we really have at our disposal. A validated care option for survivors of TBI (traumatic brain injury) has no budget contribution, and is very dangerous because the primary cause of death is post-TBI suicide. ”

That’s one of the biggest problems with the incident: there is no official game plan when it comes to healing the brain. It’s not a broken arm, when you know you’re going to be in acting for a few weeks, then do physiotherapy and then go well. It’s a shoulder-to-shoulder emoji, and that’s for your neurologist. “Let’s take a stab” or “try” because there is no right path. Every brain is different.

But then things changed for Carcillo almost two years ago, when he was introduced to psilocybin by his former teammate.

“Every day anxiety and depression decreased the intensity,” he recalled of his symptoms around psilocybin “after a ceremony,” which is a guided and controlled psychedelic experience. “I remember the other day I went out to the farm without glasses, which was not normal because my light sensitivity was extreme. And then, because I wanted to find my wife and my children more often, I couldn’t wait. To run to hug again. I felt tighter. My brain I felt like the fog was rising and very remarkable and remarkable things in a very short time. “

It was a life-changing moment for Carcillo. She started to feel better. Symptoms began to subside when the maintenance dose (3-5 mg) and maintenance doses of psilocybin and other adaptogens were maintained in a specific protocol. He had a QEEG (brain mapping) and did his blood work again – something he did after each new thing he tried to see if something he had done for years was working – and this time he showed no abnormalities and his blood work was clear.

“It simply came to our notice then aha moment, “he told Sporting News in a recent telephone interview.” So I immersed myself in science and realized that TBI could be a new first aid option for survivors. I waited about a year until I got the second clear test and then I said, okay, I have enough data to start making this public. And that’s when I started putting the pieces of the puzzle together to make this a reality and build a tournament team that I know how to play. ”

This tournament team is part of a company founded by Carcillo, Wesana Health Inc. called, “a life sciences company committed to patient empowerment and the advancement of psilocybin-based medicine and to improving health and well-being.” It closed with $ 4 million in funding in January and announced on March 31, the last day of Brain Injury Awareness Month, that a successful $ 16.1 million closure closed the private location of its subscribers before it could complete its public transaction. The proceeds from the funding will be used to fund the company’s preclinical and clinical development of psychedelic therapy to treat TBI. It was also reported on Wednesday that George Steinbrenner IV had been added as a new investor joining the board of directors.

“The tremendous advances in science have given us the tools to know and better understand the effects of traumatic brain injuries, especially those that often occur in professional sports,” Steinbrenner said in a company press release, referring to how he saw athletes in his sport (automotive). “It is essential to continue to move forward in this area to provide innovative treatment options that can help recover from the neurological and psychological damage associated with this trauma.”

Clean the wiring again

Psychedelic medicine has exploded. The idea of ​​natural products like psilocybin is a psychedelic extract that occurs naturally in 200 varieties of mushrooms and is an active ingredient in magic mushrooms, and has attracted attention throughout the university. New York University, Johns Hopkins, and Mount Iinahn School in Sinai, New York, have conducted research or are studying the use of the brain to treat anxiety, depression, and post-traumatic stress disorder. disorder.

“It simply came to our notice then [an impact on] neuro-chemical and neurological activity in the brain, ”said Dr. Michael E. Hoffer of the University School of Medicine at Miami E. Miller. He is studying whether he can treat traumatic brain injury and mild PTSD using cannabidiol (CBD) and psilocybin pills.

“In other words, we know you don’t take something like that and you think you feel different. There are certainly chemical pathways in the brain that contain the metabolites psilocybin or psilocybin. So there are some changes in brain activity when you take this compound.”

“We know where psilocybin and its metabolites play a role in the brain; that has been described, “Hoffer added later in an interview with Sporting News.” How these interactions appear in different ways in the brain is not yet well understood. “

In the United States, the Department of Drug Enforcement has labeled psilocybin as a Program I drug. In the northern border of Canada, mushrooms are illegal under the Controlled Drugs and Substances Act (CDSA). The stigma surrounding the drug has gone down. Oregon, for example, was overtaken Voting Size 109 in November he decriminalized psilocybin and protected it as a therapeutic use. In Canada, exceptions have been made for end-of-life patients, therapists who want to use psilocybin understand how their patients would work and others.

That’s what Carcillo and Wesana Health are doing. The company will soon conduct preclinical trials with drug-assisted psychedelic therapy to treat TBI-related depression in conjunction with the U.S. Food and Drug Administration and Health Canada.

“We have a specific protocol,” Carcillo said. “Charging doses are higher doses, usually between three and five grams. What this does is disruptive destructive thought patterns, close regions of our brain due to emotional or physical trauma, and help us create these new environments and neurological. In five hours it is not. nothing solidifies, so you need to keep introducing these drugs that increase BDNF (brain-derived neurotrophic factor). ”

“At the level of hallucinogens or below perception, you can continue with daily activities,” Carcillo later said, adding that he was on psilocybin during the interview. “You can get into language better, you can be more creative. It’s a mood lift, and that’s what it does in humor and personality, not to mention what it does with the brain. Then in higher doses, it’s 3-5 grams to break the destructive thought pattern and re-wire your brain. when you start “.

Carcillo and others are convinced that psilocybin can help TBI survive, not everyone is convinced.

Sporting News turned to Dr. Stephen Ross, an associate professor of psychiatry and associate director of the Center for Psychedelic Medicine at NYU Langone Health, to discuss its use in the treatment of psilocybin and TBI. He declined to be interviewed, but made the following statement through a media relations representative:

“Little is known about the use of psilocybin in the treatment of TBI. The therapeutic effects of psychedelics to treat TBI are highly speculative – although within the scope of the options, some new neurobiological findings with psychedelics have been reported in terms of neurogenesis and neuroplasticity.”

‘My goal is to help a million people’

As things progressed with Wesana Health, the ultimate goal of the former NHL executive nicknamed “Car Bomb” who collected more than 1,200 penalty minutes during his career is to help people, to protect people, as he did on the ice. . He has talked to TBI survivors for the past six years and understands better than anyone what they are going through. He understands how frightening it is to deal with the unknown and uncertainty. He has asked himself the same questions: will I get better? Will I be back before I get hurt who I was? How much longer will my symptoms last? When will it happen? How much longer do I need to suffer?

Carcillo knows everything from his experience playing professional hockey, and while focusing on his new business and the work he’s doing, he has stated that the NHL will still be held accountable for its stance on beatings and brain injuries.

“I’m not going anywhere,” he said. “The reason I know so much about convulsions is because of that. So I can actually say this, I can rest my head on the pillow, I’m not angry. I’m very happy. I play and keep playing the way I keep playing, because it still feeds me. And here we are. TBI is on the verge of providing new care opportunities for survivors. F- It’s amazing. “

This opportunity is for TBI survivors across the spectrum: athletes, veterans, survivors of domestic violence. And Carcillo wants to show them that they too can do better, and that there is hope. He speaks passionately about psilocybin, because after years of suffering, spending thousands and thousands of dollars, getting to his breaking point, his life changed for the better. But he quickly points out that psilocybin is not a miracle drug – it “shakes the snow globe” – and that a lot of work needs to be done in addition to its use.

And, he adds, people have to wait for science, both in research and for the protection of everything that is being said.

“They shouldn’t listen to me. They really shouldn’t do it,” he said when asked if anyone should follow his path. “They should wait until the job is done. I’m telling my story. I don’t need people to listen to validate it. That’s why I’m raising hundreds of millions of dollars to go to the FDA. The process of validating what happened to me. That’s why we’re here. That’s why we’re talking. This is what it’s doing.” what I am doing and will continue to do, I know that TBI is the way for survivors.

“And I’m going to help people. My goal is to help a million people, and that’s what I’m going to achieve before my life is over.”

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