Scientists create Monkey-Human Embryos
Human / animal chimeras can also help fill gaps in the understanding of early human development vision, and improved the study of the functioning of viruses, bacteria, drugs, and devices in humans, according to Farahany and Greely.
“The animal models we have right now are not enough to model most of the diseases that humans suffer from – in particular brain diseases that humans suffer, but really any disease, “Farahany said.” That means when you try to test the medication or you try to understand how a disease arises or develops, we don’t have a very good model right now. ”
For example, why this human / animal chimera Zika virus it causes birth defects in children of infected pregnant children, Farahany said.
In 2017, members of this research group reported that human cells were inserted into early-stage pig tissues, but the contribution of human cells was relatively small.
So the researchers set out to create a chimney in a species more closely related to humans, a macaque species of monkey.
Six days after the creation of 132 monkey embryos in the laboratory, 25 human cells were injected into each.
After 10 days, 103 chimeric embryos were still developing. Survival soon began to decline and by day 19 only three chimeras were still alive.
Importantly, the percentage of human cells in embryos continued to grow high all the time, the researchers said – that is, human cells were being integrated into host monkey species.
“Human cells have survived, multiplied and created several … cell lines” within the embryos of monkeys, said lead researcher Juan Carlos Izpisua Belmonte, a professor of the Gene Expression Laboratory for Biological Studies at the Salk Institute in La Jolla, California.
The creation of such human / monkey chimeras will “allow us to know if there are any barriers to the evolution of chimera creation and to find ways to overcome them,” Izpisua Belmont said in a press release.
According to Greely, “there has been hope that human cells would work better in monkey embryos, and they can guess why they have worked better in monkey embryos and can use that knowledge to make them work better in pig embryos.”