Treatments can help women who are early in menopause to be fertile
MONDAY, April 5, 2021 (HealthDay News) – Experimental treatment can be resumed fertility at the beginning of menopause, a small new study claims.
Usually, menopause ends a woman’s ability got pregnant. Researchers report that administration of platelets, which are rich in platelets, called gonadotropins, can stimulate ovulation. pregnancy possible.
“The most amazing finding in this work is waking up the beauty of sleep, restoring ovulation function after menopause,” said Dr. Chao Chin Hsu, of the Department of Obstetrics and Gynecology at Taiwan National University Hospital in Taipei.
As women enter menopause ovaries they lose normal function and contain less than 1,000 follicles in immature ovaries. These immature follicles are usually resistant to gonadotropin or other stimulants, he said.
More women delay pregnancy until it becomes a problem, and about 12% of women experience early menopause when ovarian function ends at age 45 or earlier.
These women typically need donor eggs to be able to get pregnant, but techniques that stimulate ovarian function will allow the woman to become pregnant without the help of donors.
Researchers believe that these preliminary results may give women who started menopause one day hope to become pregnant in vitro fertilization using their eggs.
Although platelet-rich plasma has been tried in women whose ovaries do not function, only a few pregnancies and births have occurred.
In this pilot study, however, when women were injected with plasma and gonadotropins containing a large number of 12 ovarian plaques, 11 began menstruating again and one became pregnant.
“This treatment is another scenario for women who are at the beginning of menopause and near-ovarian failure to have a better chance of understanding using their eggs,” Hsu said.
“Our research has shown that recovery of follicle growth with high levels of estradiol ovarian hormone in our menopausal women has received our treatment, resulting in rejuvenation of early menopausal women,” Hsu said.
It can also relieve the initial symptoms of menopause, he said. “This treatment may help prevent osteoporosis and cardiovascular disease, or even dementia in menopausal women, but this needs future testing to prove it,” Hsu said.
The findings have just been published online in the journal Menopause.
Dr. Jennifer Wu, an obstetrician-gynecologist at Lenox Hill Hospital in New York City, was not part of the study, but reviewed the findings. He believes the study has few women to draw definitive conclusions.
“The percentage of success born alive is not known, and that’s what we’re really interested in,” Wu said. “We can’t extrapolate that from those small numbers, but it’s very interesting and maybe it would work for younger patients who we call reduced ovarian reserve.”
In the small reserve of the ovary, the ovaries lose their normal reproductive capacity. It can be a disease or injury, but it usually occurs as a result of normal aging. About 10-30% of women with infertility have the disease, and it is a challenge to treat.
Wu is skeptical that this treatment used in the study will benefit menopausal women.
Most elderly patients will find it very difficult to get pregnant, and even if they do become pregnant, they will often have an abnormal pregnancy that does not end, she said.
“The problem with stimulants and eggs is that the eggs may be there, but they may not be normal at that age,” Wu said. “Even if you get pregnant, it’s not a good pregnancy. So the question is whether this technology will work better because you’re a little younger and have fewer eggs for a patient with problems.”
For more information on the onset of menopause, see American Pregnancy Association.
SOURCES: Chao Chin Hsu, MD, PhD, Department of Obstetrics and Gynecology, Taiwan National University Hospital, Taipei, Taiwan; Jennifer Wu, MD, obstetrician-gynecologist, Lenox Hill Hospital, New York City; Menopause, March 31, 2021, online